In bringing home a new puppy, you have to consider that he would be looking for his mother as well as the other puppies that he has been with.
Making him relax in his new environment would help him respond to your training positively.
To achieve that, you can place a warm hot water bottle beside his bed and a ticking clock inside the room, so that he would feel similar things as he did when he was still in his litter.
Be with your puppy as much as you can
When your puppy is left by himself for long periods of time, it may lead to practicing destructive behavior, especially when he gets bored.
Thus, you should spend as much time with your puppy as you can on a regular basis.
Have a healthy playtime, such as playing fetch would help a lot not just in establishing your connection with him, but also in preventing boredom.